diff --git a/pkgs/development/libraries/SDL2/default.nix b/pkgs/development/libraries/SDL2/default.nix
index 1ce2b1525f0..0112748695e 100644
--- a/pkgs/development/libraries/SDL2/default.nix
+++ b/pkgs/development/libraries/SDL2/default.nix
@@ -22,6 +22,7 @@
 , waylandSupport ? stdenv.isLinux && !stdenv.hostPlatform.isAndroid
 , wayland
 , wayland-protocols
+, wayland-scanner
 , drmSupport ? stdenv.isLinux && !stdenv.hostPlatform.isAndroid
 , libdrm
 , mesa
@@ -76,9 +77,18 @@ stdenv.mkDerivation rec {
     ./find-headers.patch
   ];
 
+  postPatch = ''
+    # Fix running wayland-scanner for the build platform when cross-compiling.
+    # See comment here: https://github.com/libsdl-org/SDL/issues/4860#issuecomment-1119003545
+    substituteInPlace configure \
+      --replace '$(WAYLAND_SCANNER)' 'wayland-scanner'
+  '';
+
+  strictDeps = true;
+
   depsBuildBuild = [ pkg-config ];
 
-  nativeBuildInputs = [ pkg-config ] ++ optionals waylandSupport [ wayland ];
+  nativeBuildInputs = [ pkg-config ] ++ optionals waylandSupport [ wayland wayland-scanner ];
 
   propagatedBuildInputs = dlopenPropagatedBuildInputs;