diff --git a/pkgs/applications/emulators/box64/default.nix b/pkgs/applications/emulators/box64/default.nix
new file mode 100644
index 00000000000..e383333c420
--- /dev/null
+++ b/pkgs/applications/emulators/box64/default.nix
@@ -0,0 +1,66 @@
+{ lib
+, stdenv
+, fetchFromGitHub
+, cmake
+, python3
+}:
+
+stdenv.mkDerivation rec {
+  pname = "box64";
+  version = "0.1.8";
+
+  src = fetchFromGitHub {
+    owner = "ptitSeb";
+    repo = pname;
+    rev = "v${version}";
+    hash = "sha256-6k8Enbafnj19ATtgmw8W7LxtRpM3Ousj1bpZbbtq8TM=";
+  };
+
+  nativeBuildInputs = [
+    cmake
+    python3
+  ];
+
+  cmakeFlags = [
+    "-DNOGIT=1"
+  ] ++ (
+    if stdenv.hostPlatform.system == "aarch64-linux" then
+      [
+        "-DARM_DYNAREC=ON"
+      ]
+    else [
+      "-DLD80BITS=1"
+      "-DNOALIGN=1"
+    ]
+  );
+
+  installPhase = ''
+    runHook preInstall
+    install -Dm 0755 box64 "$out/bin/box64"
+    runHook postInstall
+  '';
+
+  doCheck = true;
+
+  checkPhase = ''
+    runHook preCheck
+    ctest
+    runHook postCheck
+  '';
+
+  doInstallCheck = true;
+
+  installCheckPhase = ''
+    runHook preInstallCheck
+    $out/bin/box64 -v
+    runHook postInstallCheck
+  '';
+
+  meta = with lib; {
+    homepage = "https://box86.org/";
+    description = "Lets you run x86_64 Linux programs on non-x86_64 Linux systems";
+    license = licenses.mit;
+    maintainers = with maintainers; [ gador ];
+    platforms = [ "x86_64-linux" "aarch64-linux" ];
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index c4f7ea22b28..97a767e06fa 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -1255,6 +1255,8 @@ with pkgs;
     wxGTK = wxGTK30;
   };
 
+  box64 = callPackage ../applications/emulators/box64 { };
+
   caprice32 = callPackage ../applications/emulators/caprice32 { };
 
   ccemux = callPackage ../applications/emulators/ccemux { };