diff --git a/pkgs/os-specific/darwin/moltenvk/default.nix b/pkgs/os-specific/darwin/moltenvk/default.nix
index b2bc7e376b5..14d6287c479 100644
--- a/pkgs/os-specific/darwin/moltenvk/default.nix
+++ b/pkgs/os-specific/darwin/moltenvk/default.nix
@@ -192,6 +192,7 @@ stdenvNoCC.mkDerivation rec {
     homepage = "https://github.com/KhronosGroup/MoltenVK";
     changelog = "https://github.com/KhronosGroup/MoltenVK/releases";
     maintainers = [ lib.maintainers.reckenrode ];
+    hydraPlatforms = [ ]; # Prevent building on Hydra until MoltenVK no longer requires Xcode.
     license = lib.licenses.asl20;
     platforms = lib.platforms.darwin;
   };
diff --git a/pkgs/top-level/wine-packages.nix b/pkgs/top-level/wine-packages.nix
index c8bdaeb426e..d50b979fdce 100644
--- a/pkgs/top-level/wine-packages.nix
+++ b/pkgs/top-level/wine-packages.nix
@@ -12,7 +12,8 @@ rec {
     fontconfigSupport = stdenv.isLinux;
     alsaSupport = stdenv.isLinux;
     openglSupport = true;
-    vulkanSupport = true;
+    # Works on Darwin but disabled by default to prevent Hydra build failures due to MoltenVK.
+    vulkanSupport = stdenv.isLinux;
     tlsSupport = true;
     cupsSupport = true;
     dbusSupport = stdenv.isLinux;
@@ -40,7 +41,8 @@ rec {
     gphoto2Support = true;
     krb5Support = true;
     ldapSupport = true;
-    vkd3dSupport = true;
+    # Works on Darwin but disabled by default to prevent Hydra build failures due to MoltenVK.
+    vkd3dSupport = stdenv.isLinux;
     embedInstallers = true;
   };