diff --git a/pkgs/applications/networking/syncplay/default.nix b/pkgs/applications/networking/syncplay/default.nix
index 4927bc51b23..96420ff04de 100644
--- a/pkgs/applications/networking/syncplay/default.nix
+++ b/pkgs/applications/networking/syncplay/default.nix
@@ -14,7 +14,7 @@ buildPythonApplication rec {
   };
 
   propagatedBuildInputs = [ twisted certifi ]
-    ++ twisted.extras.tls
+    ++ twisted.extras-require.tls
     ++ lib.optional enableGUI pyside2;
   nativeBuildInputs = lib.optionals enableGUI [ qt5.wrapQtAppsHook ];
 
diff --git a/pkgs/applications/office/paperless-ngx/default.nix b/pkgs/applications/office/paperless-ngx/default.nix
index dce6869f36e..17a1a56b769 100644
--- a/pkgs/applications/office/paperless-ngx/default.nix
+++ b/pkgs/applications/office/paperless-ngx/default.nix
@@ -122,7 +122,7 @@ py.pkgs.pythonPackages.buildPythonApplication rec {
     threadpoolctl
     tika
     tqdm
-    twisted.extras.tls
+    twisted.extras-require.tls
     txaio
     tzlocal
     urllib3
diff --git a/pkgs/development/python-modules/buildbot/default.nix b/pkgs/development/python-modules/buildbot/default.nix
index 743c9f2c4b1..2eff37314e8 100644
--- a/pkgs/development/python-modules/buildbot/default.nix
+++ b/pkgs/development/python-modules/buildbot/default.nix
@@ -53,7 +53,7 @@ let
       unidiff
     ]
       # tls
-      ++ twisted.extras.tls;
+      ++ twisted.extras-require.tls;
 
     checkInputs = [
       treq
diff --git a/pkgs/development/python-modules/treq/default.nix b/pkgs/development/python-modules/treq/default.nix
index c894d3103b9..1902a578ec2 100644
--- a/pkgs/development/python-modules/treq/default.nix
+++ b/pkgs/development/python-modules/treq/default.nix
@@ -20,7 +20,7 @@ buildPythonPackage rec {
     requests
     incremental
     twisted
-  ] ++ twisted.extras.tls;
+  ] ++ twisted.extras-require.tls;
 
   checkInputs = [
     httpbin
diff --git a/pkgs/development/python-modules/twisted/default.nix b/pkgs/development/python-modules/twisted/default.nix
index 02a993fdf13..8bc03b1e5cf 100644
--- a/pkgs/development/python-modules/twisted/default.nix
+++ b/pkgs/development/python-modules/twisted/default.nix
@@ -1,5 +1,6 @@
 { lib, stdenv
 , buildPythonPackage
+, pythonOlder
 , fetchPypi
 , python
 , zope_interface
@@ -14,11 +15,24 @@
 , setuptools
 , idna
 , typing-extensions
+, pyasn1
+, cryptography
+, appdirs
+, bcrypt
+, pynacl
+, pyserial
+, h2
+, priority
+, contextvars
 }:
 buildPythonPackage rec {
   pname = "Twisted";
   version = "22.4.0";
 
+  disabled = pythonOlder "3.6";
+
+  format = "setuptools";
+
   src = fetchPypi {
     inherit pname version;
     extension = "tar.gz";
@@ -27,7 +41,14 @@ buildPythonPackage rec {
 
   propagatedBuildInputs = [ zope_interface incremental automat constantly hyperlink pyhamcrest attrs setuptools typing-extensions ];
 
-  passthru.extras.tls = [ pyopenssl service-identity idna ];
+  passthru.extras-require = rec {
+    tls = [ pyopenssl service-identity idna ];
+    conch = [ pyasn1 cryptography appdirs bcrypt ];
+    conch_nacl = conch ++ [ pynacl ];
+    serial = [ pyserial ];
+    http2 = [ h2 priority ];
+    contextvars = lib.optionals (pythonOlder "3.7") [ contextvars ];
+  };
 
   # Patch t.p._inotify to point to libc. Without this,
   # twisted.python.runtime.platform.supportsINotify() == False
diff --git a/pkgs/development/python-modules/txtorcon/default.nix b/pkgs/development/python-modules/txtorcon/default.nix
index 167e090fca0..7196e88e8dd 100644
--- a/pkgs/development/python-modules/txtorcon/default.nix
+++ b/pkgs/development/python-modules/txtorcon/default.nix
@@ -13,7 +13,7 @@ buildPythonPackage rec {
 
   propagatedBuildInputs = [
     incremental twisted automat zope_interface
-  ] ++ twisted.extras.tls
+  ] ++ twisted.extras-require.tls
   ++ lib.optionals (!isPy3k) [ ipaddress ];
 
   checkInputs = [ pytestCheckHook mock lsof GeoIP ];
diff --git a/pkgs/tools/networking/p2p/tahoe-lafs/default.nix b/pkgs/tools/networking/p2p/tahoe-lafs/default.nix
index b0f4cd1f788..938bfa1dcd6 100644
--- a/pkgs/tools/networking/p2p/tahoe-lafs/default.nix
+++ b/pkgs/tools/networking/p2p/tahoe-lafs/default.nix
@@ -60,7 +60,8 @@ python3Packages.buildPythonApplication rec {
     html5lib magic-wormhole netifaces pyasn1 pycrypto pyutil pyyaml recommonmark
     service-identity simplejson sphinx_rtd_theme testtools treq twisted zfec
     zope_interface
-  ];
+  ] ++ twisted.extras-require.tls
+    ++ twisted.extras-require.conch;
 
   checkInputs = with python3Packages; [ mock hypothesis twisted ];