diff --git a/pkgs/applications/audio/hqplayer-desktop/default.nix b/pkgs/applications/audio/hqplayer-desktop/default.nix
index 38b7e040603..5cfd9c7cbe8 100644
--- a/pkgs/applications/audio/hqplayer-desktop/default.nix
+++ b/pkgs/applications/audio/hqplayer-desktop/default.nix
@@ -86,6 +86,7 @@ mkDerivation rec {
     homepage = "https://www.signalyst.com/custom.html";
     description = "High-end upsampling multichannel software HD-audio player";
     license = licenses.unfree;
+    platforms = [ "x86_64-linux" ];
     maintainers = with maintainers; [ lovesegfault ];
   };
 }
diff --git a/pkgs/applications/audio/losslessaudiochecker/default.nix b/pkgs/applications/audio/losslessaudiochecker/default.nix
index 551f56a3ce1..9fecf7b9ba9 100644
--- a/pkgs/applications/audio/losslessaudiochecker/default.nix
+++ b/pkgs/applications/audio/losslessaudiochecker/default.nix
@@ -23,7 +23,7 @@ stdenv.mkDerivation {
     description = "Utility to check whether audio is truly lossless or not";
     homepage = "https://losslessaudiochecker.com";
     license = lib.licenses.unfree;
-    platforms = lib.platforms.x86_64;
+    platforms = [ "x86_64-linux" ];
     maintainers = with lib.maintainers; [ p-h ];
   };
 }
diff --git a/pkgs/applications/audio/soundwireserver/default.nix b/pkgs/applications/audio/soundwireserver/default.nix
index 17660599b68..db8d28989b2 100755
--- a/pkgs/applications/audio/soundwireserver/default.nix
+++ b/pkgs/applications/audio/soundwireserver/default.nix
@@ -34,6 +34,7 @@ qt5.mkDerivation {
     description = "Turn your Android device into wireless headphones / wireless speaker";
     homepage = "https://georgielabs.net/";
     maintainers = with maintainers; [ mkg20001 ];
+    platforms = [ "x86_64-linux" ];
     license = licenses.unfree;
   };
 }
diff --git a/pkgs/applications/editors/pinegrow/default.nix b/pkgs/applications/editors/pinegrow/default.nix
index 3b694e4b151..4f7967c3a34 100644
--- a/pkgs/applications/editors/pinegrow/default.nix
+++ b/pkgs/applications/editors/pinegrow/default.nix
@@ -63,7 +63,7 @@ stdenv.mkDerivation rec {
   meta = with lib; {
     homepage = "https://pinegrow.com";
     description = "UI Web Editor";
-    platforms = platforms.linux;
+    platforms = [ "x86_64-linux" ];
     license = with licenses; [ unfreeRedistributable ];
     maintainers = with maintainers; [ gador ];
   };
diff --git a/pkgs/applications/graphics/pixeluvo/default.nix b/pkgs/applications/graphics/pixeluvo/default.nix
index d88be436984..0c90b786bac 100644
--- a/pkgs/applications/graphics/pixeluvo/default.nix
+++ b/pkgs/applications/graphics/pixeluvo/default.nix
@@ -50,6 +50,7 @@ stdenv.mkDerivation rec {
     description = "A Beautifully Designed Image and Photo Editor for Windows and Linux";
     homepage = "http://www.pixeluvo.com/";
     license = licenses.unfree;
+    platforms = [ "x86_64-linux" ];
     maintainers = with maintainers; [ wolfangaukang ];
   };
 }
diff --git a/pkgs/applications/misc/foxitreader/default.nix b/pkgs/applications/misc/foxitreader/default.nix
index e69361dbd93..b206d14323b 100644
--- a/pkgs/applications/misc/foxitreader/default.nix
+++ b/pkgs/applications/misc/foxitreader/default.nix
@@ -74,6 +74,7 @@ mkDerivation rec {
     description = "A viewer for PDF documents";
     homepage = "https://www.foxitsoftware.com/";
     license = licenses.unfree;
+    platforms = [ "x86_64-linux" ];
     maintainers = with maintainers; [ p-h rhoriguchi ];
   };
 }
diff --git a/pkgs/applications/misc/upwork/default.nix b/pkgs/applications/misc/upwork/default.nix
index dc50a3b9567..6ed38175eba 100644
--- a/pkgs/applications/misc/upwork/default.nix
+++ b/pkgs/applications/misc/upwork/default.nix
@@ -53,6 +53,7 @@ stdenv.mkDerivation rec {
     description = "Online freelancing platform desktop application for time tracking";
     homepage = "https://www.upwork.com/ab/downloads/";
     license = licenses.unfree;
+    platforms = [ "x86_64-linux" ];
     maintainers = with maintainers; [ zakkor wolfangaukang ];
   };
 }
diff --git a/pkgs/applications/networking/cluster/ssm-session-manager-plugin/default.nix b/pkgs/applications/networking/cluster/ssm-session-manager-plugin/default.nix
index f7401d36b0e..2caa0dc2280 100644
--- a/pkgs/applications/networking/cluster/ssm-session-manager-plugin/default.nix
+++ b/pkgs/applications/networking/cluster/ssm-session-manager-plugin/default.nix
@@ -17,7 +17,12 @@ stdenv.mkDerivation rec {
 
   src = fetchurl source;
 
-  nativeBuildInputs = [ autoPatchelfHook ] ++ (if stdenv.isDarwin then [ unzip ] else [ dpkg ]);
+  nativeBuildInputs = lib.optionals stdenv.isLinux [
+    autoPatchelfHook
+    dpkg
+  ] ++ lib.optionals stdenv.isDarwin [
+    unzip
+  ];
 
   unpackPhase = if stdenv.isDarwin then "unzip $src" else "dpkg-deb -x $src .";
 
diff --git a/pkgs/applications/networking/mailreaders/mailspring/default.nix b/pkgs/applications/networking/mailreaders/mailspring/default.nix
index d2e5beb1718..c63084f3550 100644
--- a/pkgs/applications/networking/mailreaders/mailspring/default.nix
+++ b/pkgs/applications/networking/mailreaders/mailspring/default.nix
@@ -90,6 +90,6 @@ stdenv.mkDerivation rec {
     maintainers = with maintainers; [ toschmidt doronbehar ];
     homepage = "https://getmailspring.com";
     downloadPage = "https://github.com/Foundry376/Mailspring";
-    platforms = platforms.x86_64;
+    platforms = [ "x86_64-linux" ];
   };
 }
diff --git a/pkgs/applications/networking/tetrd/default.nix b/pkgs/applications/networking/tetrd/default.nix
index 94e7950ecdb..937992a63d7 100644
--- a/pkgs/applications/networking/tetrd/default.nix
+++ b/pkgs/applications/networking/tetrd/default.nix
@@ -79,7 +79,7 @@ stdenv.mkDerivation rec {
     description = "Share your internet connection from your device to your PC and vice versa through a USB cable";
     homepage = "https://tetrd.app";
     license = licenses.unfree;
-    platforms = platforms.all;
+    platforms = [ "x86_64-linux" ];
     maintainers = with maintainers; [ Madouura ];
   };
 }
diff --git a/pkgs/applications/terminal-emulators/syncterm/default.nix b/pkgs/applications/terminal-emulators/syncterm/default.nix
index d1f0ab5e8cf..d56db734a88 100644
--- a/pkgs/applications/terminal-emulators/syncterm/default.nix
+++ b/pkgs/applications/terminal-emulators/syncterm/default.nix
@@ -34,6 +34,8 @@ stdenv.mkDerivation rec {
     homepage = "https://syncterm.bbsdev.net/";
     description = "BBS terminal emulator";
     maintainers = with maintainers; [ embr ];
+    platforms = platforms.unix;
     license = licenses.gpl2Plus;
+    broken = stdenv.isDarwin; # error: unsupported option '-fsanitize=safe-stack' for target 'x86_64-apple-darwin'
   };
 }
diff --git a/pkgs/development/compilers/dmd/binary.nix b/pkgs/development/compilers/dmd/binary.nix
index f47e447334b..fdea39db94b 100644
--- a/pkgs/development/compilers/dmd/binary.nix
+++ b/pkgs/development/compilers/dmd/binary.nix
@@ -18,8 +18,9 @@ in stdenv.mkDerivation {
   dontConfigure = true;
   dontBuild = true;
 
-  nativeBuildInputs = [ autoPatchelfHook ]
-    ++ lib.optional hostPlatform.isDarwin fixDarwinDylibNames;
+  nativeBuildInputs = lib.optionals hostPlatform.isLinux [
+    autoPatchelfHook
+  ] ++ lib.optional hostPlatform.isDarwin fixDarwinDylibNames;
   propagatedBuildInputs = [ curl tzdata ] ++ lib.optional hostPlatform.isLinux glibc;
 
   installPhase = ''
diff --git a/pkgs/development/compilers/graalvm/community-edition/mkGraal.nix b/pkgs/development/compilers/graalvm/community-edition/mkGraal.nix
index ee016e71d31..6a86b7e8141 100644
--- a/pkgs/development/compilers/graalvm/community-edition/mkGraal.nix
+++ b/pkgs/development/compilers/graalvm/community-edition/mkGraal.nix
@@ -86,7 +86,8 @@ let
       zlib
     ];
 
-    nativeBuildInputs = [ unzip perl autoPatchelfHook makeWrapper ];
+    nativeBuildInputs = [ unzip perl makeWrapper ]
+      ++ lib.optional stdenv.hostPlatform.isLinux autoPatchelfHook;
 
     unpackPhase = ''
       unpack_jar() {
diff --git a/pkgs/development/compilers/inklecate/default.nix b/pkgs/development/compilers/inklecate/default.nix
index 32b91f5ddfe..ecf5ed50ab3 100644
--- a/pkgs/development/compilers/inklecate/default.nix
+++ b/pkgs/development/compilers/inklecate/default.nix
@@ -17,7 +17,7 @@ buildDotnetModule rec {
     sha256 = "00lagmwsbxap5mgnw4gndpavmv3xsgincdaq1zvw7fkc3vn3pxqc";
   };
 
-  nativeBuildInputs = [ autoPatchelfHook ];
+  nativeBuildInputs = lib.optionals stdenv.isLinux [ autoPatchelfHook ];
   buildInputs = [ stdenv.cc.cc.lib ];
 
   projectFile = "inklecate/inklecate.csproj";
diff --git a/pkgs/development/compilers/ldc/binary.nix b/pkgs/development/compilers/ldc/binary.nix
index 05928d396c8..dd4d51c81e3 100644
--- a/pkgs/development/compilers/ldc/binary.nix
+++ b/pkgs/development/compilers/ldc/binary.nix
@@ -18,8 +18,9 @@ in stdenv.mkDerivation {
   dontConfigure = true;
   dontBuild = true;
 
-  nativeBuildInputs = [ autoPatchelfHook ]
-    ++ lib.optional hostPlatform.isDarwin fixDarwinDylibNames;
+  nativeBuildInputs = lib.optionals hostPlatform.isLinux [
+    autoPatchelfHook
+  ] ++ lib.optional hostPlatform.isDarwin fixDarwinDylibNames;
 
   buildInputs = lib.optionals stdenv.hostPlatform.isLinux [ libxml2 stdenv.cc.cc ];
 
diff --git a/pkgs/development/compilers/zulu/8.nix b/pkgs/development/compilers/zulu/8.nix
index 48573c67241..00f18f1238f 100644
--- a/pkgs/development/compilers/zulu/8.nix
+++ b/pkgs/development/compilers/zulu/8.nix
@@ -61,18 +61,22 @@ in stdenv.mkDerivation {
   ];
 
   nativeBuildInputs = [
-    autoPatchelfHook makeWrapper
+    makeWrapper
+  ] ++ lib.optionals stdenv.isLinux [
+    autoPatchelfHook
   ] ++ lib.optionals stdenv.isDarwin [
     unzip
   ];
 
   installPhase = ''
+    runHook preInstall
+
     mkdir -p $out
     cp -r ./* "$out/"
-
+  '' + lib.optionalString stdenv.isLinux ''
     # jni.h expects jni_md.h to be in the header search path.
     ln -s $out/include/linux/*_md.h $out/include/
-
+  '' + ''
     mkdir -p $out/nix-support
     printWords ${setJavaClassPath} > $out/nix-support/propagated-build-inputs
 
@@ -87,6 +91,8 @@ in stdenv.mkDerivation {
         wrapProgram "$bin" --prefix LD_LIBRARY_PATH : "${runtimeLibraryPath}"
       fi
     done
+  '' + ''
+    runHook postInstall
   '';
 
   preFixup = ''
diff --git a/pkgs/development/compilers/zulu/default.nix b/pkgs/development/compilers/zulu/default.nix
index 662d997d882..1b961c3f9e4 100644
--- a/pkgs/development/compilers/zulu/default.nix
+++ b/pkgs/development/compilers/zulu/default.nix
@@ -63,12 +63,16 @@ in stdenv.mkDerivation {
   ];
 
   nativeBuildInputs = [
-    autoPatchelfHook makeWrapper
+    makeWrapper
+  ] ++ lib.optionals stdenv.isLinux [
+    autoPatchelfHook
   ] ++ lib.optionals stdenv.isDarwin [
     unzip
   ];
 
   installPhase = ''
+    runHook preInstall
+
     mkdir -p $out
     cp -r ./* "$out/"
   '' + lib.optionalString stdenv.isLinux ''
@@ -90,6 +94,8 @@ in stdenv.mkDerivation {
     for bin in $( find "$out" -executable -type f -not -name jspawnhelper ); do
       wrapProgram "$bin" --prefix LD_LIBRARY_PATH : "${runtimeLibraryPath}"
     done
+  '' + ''
+    runHook postInstall
   '';
 
   preFixup = ''
diff --git a/pkgs/development/libraries/cutelyst/default.nix b/pkgs/development/libraries/cutelyst/default.nix
index 9f7d020feaf..d7fe4e92802 100644
--- a/pkgs/development/libraries/cutelyst/default.nix
+++ b/pkgs/development/libraries/cutelyst/default.nix
@@ -14,20 +14,28 @@ stdenv.mkDerivation rec {
   };
 
   nativeBuildInputs = [ cmake pkg-config wrapQtAppsHook ];
-  buildInputs = [ qtbase libuuid libcap uwsgi grantlee pcre ];
+  buildInputs = [
+    qtbase
+    grantlee
+  ] ++ lib.optionals stdenv.isLinux [
+    libuuid
+    libcap
+    uwsgi
+    pcre
+  ];
 
   cmakeFlags = [
-    "-DPLUGIN_UWSGI=ON"
+    "-DPLUGIN_UWSGI=${if stdenv.isLinux then "ON" else "OFF"}" # Missing uwsgi symbols on Darwin
     "-DPLUGIN_STATICCOMPRESSED=ON"
     "-DPLUGIN_CSRFPROTECTION=ON"
     "-DPLUGIN_VIEW_GRANTLEE=ON"
   ];
 
-  preBuild = ''
+  preBuild = lib.optionalString stdenv.isLinux ''
     export LD_LIBRARY_PATH="$LD_LIBRARY_PATH''${LD_LIBRARY_PATH:+:}`pwd`/Cutelyst:`pwd`/EventLoopEPoll"
   '';
 
-  postBuild = ''
+  postBuild = lib.optionalString stdenv.isLinux ''
     unset LD_LIBRARY_PATH
   '';
 
@@ -35,6 +43,7 @@ stdenv.mkDerivation rec {
     description = "C++ Web Framework built on top of Qt";
     homepage = "https://cutelyst.org/";
     license = licenses.lgpl21Plus;
+    platforms = platforms.unix;
     maintainers = with maintainers; [ fpletz ];
   };
 }
diff --git a/pkgs/development/libraries/openvino/default.nix b/pkgs/development/libraries/openvino/default.nix
index 86bc3b0d009..b6f4a0f1bb1 100644
--- a/pkgs/development/libraries/openvino/default.nix
+++ b/pkgs/development/libraries/openvino/default.nix
@@ -129,6 +129,8 @@ stdenv.mkDerivation rec {
     '';
     homepage = "https://docs.openvinotoolkit.org/";
     license = with licenses; [ asl20 ];
+    platforms = platforms.all;
+    broken = stdenv.isDarwin; # Cannot find macos sdk
     maintainers = with maintainers; [ tfmoraes ];
   };
 }
diff --git a/pkgs/development/misc/msp430/mspds/binary.nix b/pkgs/development/misc/msp430/mspds/binary.nix
index 2fc306f8e5f..967562580c6 100644
--- a/pkgs/development/misc/msp430/mspds/binary.nix
+++ b/pkgs/development/misc/msp430/mspds/binary.nix
@@ -17,7 +17,8 @@ in stdenv.mkDerivation rec {
     if stdenv.hostPlatform.isWindows then "MSP430${archPostfix}.dll"
     else "libmsp430${archPostfix}${stdenv.hostPlatform.extensions.sharedLibrary}";
 
-  nativeBuildInputs = [ unzip autoPatchelfHook ];
+  nativeBuildInputs = [ unzip ]
+    ++ lib.optional stdenv.isLinux autoPatchelfHook;
   buildInputs = [ stdenv.cc.cc ];
 
   installPhase = ''
diff --git a/pkgs/development/mobile/androidenv/build-tools.nix b/pkgs/development/mobile/androidenv/build-tools.nix
index 536a025d15b..641560f1992 100644
--- a/pkgs/development/mobile/androidenv/build-tools.nix
+++ b/pkgs/development/mobile/androidenv/build-tools.nix
@@ -2,8 +2,8 @@
 
 deployAndroidPackage {
   inherit package os;
-  buildInputs = [ autoPatchelfHook makeWrapper ] ++
-    lib.optionals (os == "linux") [ pkgs.glibc pkgs.zlib pkgs.ncurses5 pkgs_i686.glibc pkgs_i686.zlib pkgs_i686.ncurses5 pkgs.libcxx ];
+  buildInputs = [ makeWrapper ] ++
+    lib.optionals (os == "linux") [ autoPatchelfHook pkgs.glibc pkgs.zlib pkgs.ncurses5 pkgs_i686.glibc pkgs_i686.zlib pkgs_i686.ncurses5 pkgs.libcxx ];
   patchInstructions = ''
     ${lib.optionalString (os == "linux") ''
       addAutoPatchelfSearchPath $packageBaseDir/lib
diff --git a/pkgs/development/mobile/androidenv/platform-tools.nix b/pkgs/development/mobile/androidenv/platform-tools.nix
index c39d966959a..52443486bbb 100644
--- a/pkgs/development/mobile/androidenv/platform-tools.nix
+++ b/pkgs/development/mobile/androidenv/platform-tools.nix
@@ -2,8 +2,7 @@
 
 deployAndroidPackage {
   inherit package os;
-  buildInputs = [ autoPatchelfHook ]
-    ++ lib.optionals (os == "linux") [ pkgs.glibc pkgs.zlib pkgs.ncurses5 ];
+  buildInputs = lib.optionals (os == "linux") [ autoPatchelfHook pkgs.glibc pkgs.zlib pkgs.ncurses5 ];
   patchInstructions = lib.optionalString (os == "linux") ''
     addAutoPatchelfSearchPath $packageBaseDir/lib64
     autoPatchelf --no-recurse $packageBaseDir/lib64
diff --git a/pkgs/development/python-modules/wxPython/4.1.nix b/pkgs/development/python-modules/wxPython/4.1.nix
index 71f8b2847e3..e5942c17d4c 100644
--- a/pkgs/development/python-modules/wxPython/4.1.nix
+++ b/pkgs/development/python-modules/wxPython/4.1.nix
@@ -48,12 +48,14 @@ buildPythonPackage rec {
     doxygen
     wxGTK.gtk
     pkg-config
+  ] ++ lib.optionals stdenv.isLinux [
     autoPatchelfHook
   ];
 
   buildInputs = [
     wxGTK.gtk
     ncurses
+  ] ++ lib.optionals stdenv.isLinux [
     libXinerama
     libSM
     libXxf86vm
diff --git a/pkgs/development/tools/analysis/codeql/default.nix b/pkgs/development/tools/analysis/codeql/default.nix
index a6a95e74e4a..3f22bd7c30b 100644
--- a/pkgs/development/tools/analysis/codeql/default.nix
+++ b/pkgs/development/tools/analysis/codeql/default.nix
@@ -43,6 +43,7 @@ stdenv.mkDerivation rec {
     description = "Semantic code analysis engine";
     homepage = "https://codeql.github.com";
     maintainers = [ maintainers.dump_stack ];
+    platforms = [ "x86_64-linux" ];
     license = licenses.unfree;
   };
 }
diff --git a/pkgs/development/tools/build-managers/bazel/bazel_0_29/default.nix b/pkgs/development/tools/build-managers/bazel/bazel_0_29/default.nix
index 0ecf6300eb2..9f2fb8b40f4 100644
--- a/pkgs/development/tools/build-managers/bazel/bazel_0_29/default.nix
+++ b/pkgs/development/tools/build-managers/bazel/bazel_0_29/default.nix
@@ -112,7 +112,8 @@ let
 
     src = srcDepsSet."java_tools_javac11_${system}-v4.0.zip";
 
-    nativeBuildInputs = [ autoPatchelfHook unzip ];
+    nativeBuildInputs = [ unzip ]
+      ++ lib.optional stdenv.isLinux autoPatchelfHook;
     buildInputs = [ gcc-unwrapped ];
 
     sourceRoot = ".";
diff --git a/pkgs/development/tools/build-managers/bazel/bazel_1/default.nix b/pkgs/development/tools/build-managers/bazel/bazel_1/default.nix
index 3adf52ec905..0402fb85f26 100644
--- a/pkgs/development/tools/build-managers/bazel/bazel_1/default.nix
+++ b/pkgs/development/tools/build-managers/bazel/bazel_1/default.nix
@@ -112,7 +112,8 @@ let
 
     src = srcDepsSet."java_tools_javac11_${system}-v6.1.zip";
 
-    nativeBuildInputs = [ autoPatchelfHook unzip ];
+    nativeBuildInputs = [ unzip ]
+      ++ lib.optional stdenv.isLinux autoPatchelfHook;
     buildInputs = [ gcc-unwrapped ];
 
     sourceRoot = ".";
diff --git a/pkgs/development/tools/build-managers/bazel/bazel_3/default.nix b/pkgs/development/tools/build-managers/bazel/bazel_3/default.nix
index 3c71c8cc089..3a5c9e2e76f 100644
--- a/pkgs/development/tools/build-managers/bazel/bazel_3/default.nix
+++ b/pkgs/development/tools/build-managers/bazel/bazel_3/default.nix
@@ -117,7 +117,8 @@ let
 
     src = srcDepsSet."java_tools_javac11_${system}-v10.0.zip";
 
-    nativeBuildInputs = [ autoPatchelfHook unzip ];
+    nativeBuildInputs = [ unzip ]
+      ++ lib.optional stdenv.isLinux autoPatchelfHook;
     buildInputs = [ gcc-unwrapped ];
 
     sourceRoot = ".";
diff --git a/pkgs/development/tools/build-managers/bazel/bazel_4/default.nix b/pkgs/development/tools/build-managers/bazel/bazel_4/default.nix
index 72c971d1334..79bb378534b 100644
--- a/pkgs/development/tools/build-managers/bazel/bazel_4/default.nix
+++ b/pkgs/development/tools/build-managers/bazel/bazel_4/default.nix
@@ -142,7 +142,8 @@ let
 
     src = srcDepsSet."java_tools_javac11_${system}-v10.6.zip";
 
-    nativeBuildInputs = [ autoPatchelfHook unzip ];
+    nativeBuildInputs = [ unzip ]
+      ++ lib.optional stdenv.isLinux autoPatchelfHook;
     buildInputs = [ gcc-unwrapped ];
 
     sourceRoot = ".";
diff --git a/pkgs/development/tools/build-managers/bloop/default.nix b/pkgs/development/tools/build-managers/bloop/default.nix
index 11b25bec381..94e6fc70f7d 100644
--- a/pkgs/development/tools/build-managers/bloop/default.nix
+++ b/pkgs/development/tools/build-managers/bloop/default.nix
@@ -66,7 +66,8 @@ stdenv.mkDerivation rec {
   };
 
   dontUnpack = true;
-  nativeBuildInputs = [ autoPatchelfHook installShellFiles makeWrapper ];
+  nativeBuildInputs = [ installShellFiles makeWrapper ]
+    ++ lib.optional stdenv.isLinux autoPatchelfHook;
   buildInputs = [ stdenv.cc.cc.lib zlib ];
   propagatedBuildInputs = [ jre ];
 
diff --git a/pkgs/development/tools/build-managers/scala-cli/default.nix b/pkgs/development/tools/build-managers/scala-cli/default.nix
index c045944b773..30fa7f3c658 100644
--- a/pkgs/development/tools/build-managers/scala-cli/default.nix
+++ b/pkgs/development/tools/build-managers/scala-cli/default.nix
@@ -16,7 +16,8 @@ in
 stdenv.mkDerivation {
   pname = "scala-cli";
   inherit version;
-  nativeBuildInputs = [ autoPatchelfHook installShellFiles ];
+  nativeBuildInputs = [ installShellFiles ]
+    ++ lib.optional stdenv.isLinux autoPatchelfHook;
   buildInputs = [ coreutils zlib stdenv.cc.cc ];
   src =
     let
@@ -42,9 +43,9 @@ stdenv.mkDerivation {
   # We need to call autopatchelf before generating completions
   dontAutoPatchelf = true;
 
-  postFixup = ''
+  postFixup = lib.optionalString stdenv.isLinux ''
     autoPatchelf $out
-
+  '' + ''
     # hack to ensure the completion function looks right
     # as $0 is used to generate the compdef directive
     PATH="$out/bin:$PATH"
diff --git a/pkgs/development/tools/ccloud-cli/default.nix b/pkgs/development/tools/ccloud-cli/default.nix
index 5814ab90e6d..2a3d1de41a1 100644
--- a/pkgs/development/tools/ccloud-cli/default.nix
+++ b/pkgs/development/tools/ccloud-cli/default.nix
@@ -14,7 +14,7 @@ stdenv.mkDerivation rec {
       sha256 = "0936hipcl37w4mzzsnjlz4q1z4j9094i4irigzqwg14gdbs7p11s";
     });
 
-  nativeBuildInputs = [ autoPatchelfHook ];
+  nativeBuildInputs = lib.optionals stdenv.hostPlatform.isLinux [ autoPatchelfHook ];
 
   dontStrip = stdenv.isDarwin;
 
diff --git a/pkgs/development/tools/confluent-cli/default.nix b/pkgs/development/tools/confluent-cli/default.nix
index 9664a75703a..059a3272038 100644
--- a/pkgs/development/tools/confluent-cli/default.nix
+++ b/pkgs/development/tools/confluent-cli/default.nix
@@ -14,7 +14,7 @@ stdenv.mkDerivation rec {
       sha256 = "1wvy7x56cc7imycf0d83mxcqzdvv56cc0zbp913xgghjn9dl2z7a";
     });
 
-  nativeBuildInputs = [ autoPatchelfHook ];
+  nativeBuildInputs = lib.optionals stdenv.hostPlatform.isLinux [ autoPatchelfHook ];
 
   dontStrip = stdenv.isDarwin;
 
diff --git a/pkgs/development/tools/mold/default.nix b/pkgs/development/tools/mold/default.nix
index 00bcd3a5f12..ba803afac87 100644
--- a/pkgs/development/tools/mold/default.nix
+++ b/pkgs/development/tools/mold/default.nix
@@ -41,6 +41,8 @@ stdenv.mkDerivation rec {
     homepage = "https://github.com/rui314/mold";
     license = lib.licenses.agpl3Plus;
     maintainers = with maintainers; [ nitsky ];
-    broken = stdenv.isAarch64;
+    platforms = platforms.unix;
+    # error: aligned deallocation function of type 'void (void *, std::align_val_t) noexcept' is only available on macOS 10.14 or newer
+    broken = stdenv.isAarch64 || stdenv.isDarwin;
   };
 }
diff --git a/pkgs/servers/hqplayerd/default.nix b/pkgs/servers/hqplayerd/default.nix
index 7b65a789af8..64a5fd18381 100644
--- a/pkgs/servers/hqplayerd/default.nix
+++ b/pkgs/servers/hqplayerd/default.nix
@@ -130,6 +130,7 @@ stdenv.mkDerivation rec {
     homepage = "https://www.signalyst.com/custom.html";
     description = "High-end upsampling multichannel software embedded HD-audio player";
     license = licenses.unfree;
+    platforms = [ "x86_64-linux" ];
     maintainers = with maintainers; [ lovesegfault ];
   };
 }
diff --git a/pkgs/servers/ombi/default.nix b/pkgs/servers/ombi/default.nix
index a99349d8c0d..93eab0bd683 100644
--- a/pkgs/servers/ombi/default.nix
+++ b/pkgs/servers/ombi/default.nix
@@ -26,7 +26,8 @@ in stdenv.mkDerivation rec {
     sha256 = hash;
   };
 
-  nativeBuildInputs = [ makeWrapper autoPatchelfHook ]
+  nativeBuildInputs = [ makeWrapper ]
+    ++ lib.optional stdenv.hostPlatform.isLinux autoPatchelfHook
     ++ lib.optional stdenv.hostPlatform.isDarwin fixDarwinDylibNames;
 
   propagatedBuildInputs = [ stdenv.cc.cc zlib krb5 ];
diff --git a/pkgs/servers/search/elasticsearch/6.x.nix b/pkgs/servers/search/elasticsearch/6.x.nix
index 56f0779c833..798fa83e6d5 100644
--- a/pkgs/servers/search/elasticsearch/6.x.nix
+++ b/pkgs/servers/search/elasticsearch/6.x.nix
@@ -62,9 +62,10 @@ stdenv.mkDerivation (rec {
   };
 } // optionalAttrs enableUnfree {
   dontPatchELF = true;
-  nativeBuildInputs = [ makeWrapper autoPatchelfHook ];
+  nativeBuildInputs = [ makeWrapper ]
+    ++ optional stdenv.isLinux autoPatchelfHook;
   runtimeDependencies = [ zlib ];
-  postFixup = ''
+  postFixup = lib.optionalString stdenv.isLinux ''
     for exe in $(find $out/modules/x-pack-ml/platform/linux-x86_64/bin -executable -type f); do
       echo "patching $exe..."
       patchelf --set-interpreter "$(cat $NIX_CC/nix-support/dynamic-linker)" "$exe"
diff --git a/pkgs/servers/search/elasticsearch/7.x.nix b/pkgs/servers/search/elasticsearch/7.x.nix
index 592cc947a42..b93c9da593f 100644
--- a/pkgs/servers/search/elasticsearch/7.x.nix
+++ b/pkgs/servers/search/elasticsearch/7.x.nix
@@ -44,7 +44,8 @@ stdenv.mkDerivation rec {
       "ES_CLASSPATH=\"\$ES_CLASSPATH:$out/\$additional_classpath_directory/*\""
   '';
 
-  nativeBuildInputs = [ autoPatchelfHook makeWrapper ];
+  nativeBuildInputs = [ makeWrapper ]
+    ++ optional stdenv.isLinux autoPatchelfHook;
 
   buildInputs = [ jre_headless util-linux zlib ];
 
diff --git a/pkgs/servers/web-apps/virtlyst/default.nix b/pkgs/servers/web-apps/virtlyst/default.nix
index 3ff42050eb2..d6a72916fae 100644
--- a/pkgs/servers/web-apps/virtlyst/default.nix
+++ b/pkgs/servers/web-apps/virtlyst/default.nix
@@ -18,9 +18,13 @@ stdenv.mkDerivation rec {
   dontWrapQtApps = true;
 
   installPhase = ''
+    runHook preInstall
+
     mkdir -p $out/lib
-    cp src/libVirtlyst.so $out/lib
+    cp src/libVirtlyst${stdenv.hostPlatform.extensions.sharedLibrary} $out/lib
     cp -r ../root $out
+
+    runHook postInstall
   '';
 
   patches = [ ./add-admin-password-env.patch ];
@@ -29,6 +33,7 @@ stdenv.mkDerivation rec {
     description = "Web interface to manage virtual machines with libvirt";
     homepage = "https://github.com/cutelyst/Virtlyst";
     license = licenses.agpl3Plus;
+    platforms = platforms.unix;
     maintainers = with maintainers; [ fpletz ];
   };
 }
diff --git a/pkgs/shells/powershell/default.nix b/pkgs/shells/powershell/default.nix
index 4efa2cd88a7..1233b23f3ca 100644
--- a/pkgs/shells/powershell/default.nix
+++ b/pkgs/shells/powershell/default.nix
@@ -29,7 +29,8 @@ stdenv.mkDerivation rec {
   };
 
   buildInputs = [ less ] ++ libraries;
-  nativeBuildInputs = [ autoPatchelfHook makeWrapper ];
+  nativeBuildInputs = [ makeWrapper ]
+    ++ lib.optional stdenv.isLinux autoPatchelfHook;
 
   installPhase =
   let
diff --git a/pkgs/tools/archivers/rar/default.nix b/pkgs/tools/archivers/rar/default.nix
index a359beb21ad..5a0d7e51e72 100644
--- a/pkgs/tools/archivers/rar/default.nix
+++ b/pkgs/tools/archivers/rar/default.nix
@@ -32,7 +32,8 @@ stdenv.mkDerivation rec {
 
   buildInputs = [ stdenv.cc.cc.lib ];
 
-  nativeBuildInputs = [ autoPatchelfHook installShellFiles ];
+  nativeBuildInputs = [ installShellFiles ]
+    ++ lib.optional stdenv.isLinux autoPatchelfHook;
 
   installPhase = ''
     runHook preInstall
diff --git a/pkgs/tools/games/ajour/default.nix b/pkgs/tools/games/ajour/default.nix
index 49fef3edca9..11df34256d4 100644
--- a/pkgs/tools/games/ajour/default.nix
+++ b/pkgs/tools/games/ajour/default.nix
@@ -1,4 +1,5 @@
-{ lib
+{ stdenv
+, lib
 , fetchFromGitHub
 , rustPlatform
 , autoPatchelfHook
@@ -79,6 +80,7 @@ in rustPlatform.buildRustPackage rec {
     homepage = "https://github.com/casperstorm/ajour";
     changelog = "https://github.com/casperstorm/ajour/blob/master/CHANGELOG.md";
     license = licenses.mit;
+    broken = stdenv.isDarwin;
     maintainers = with maintainers; [ hexa ];
   };
 }
diff --git a/pkgs/tools/misc/archi/default.nix b/pkgs/tools/misc/archi/default.nix
index d0beb7d40d7..e6f16b93f7d 100644
--- a/pkgs/tools/misc/archi/default.nix
+++ b/pkgs/tools/misc/archi/default.nix
@@ -30,9 +30,8 @@ stdenv.mkDerivation rec {
   ];
 
   nativeBuildInputs = [
-    autoPatchelfHook
     makeWrapper
-  ];
+  ] ++ lib.optional stdenv.hostPlatform.isLinux autoPatchelfHook;
 
   installPhase =
     if stdenv.hostPlatform.system == "x86_64-linux" then